Journal: eNeuro

Article Title: Syn3 Gene Knockout Negatively Impacts Aspects of Reversal Learning Performance

doi: 10.1523/ENEURO.0251-21.2021

Figure Lengend Snippet: Contingency reversal increases anticipatory responses, but Syn3 ablation reduces anticipatory responses compared to wildtype mice. Cumming estimation plot displaying anticipatory responses per trial in discrimination and reversal phases within each genotype group. The line plot in the top panel shows individual data for mice in each genotype group. Paired mean differences comparing discrimination and reversal performance within each group are in the middle panel. Unpaired mean differences comparing each mutant group to the wildtype control group are shown in the bottom panel.

Article Snippet: Offspring were genotyped for dosage of wild-type and mutant Syn3 alleles by Transnetyx from ear tissue collected at weaning.

Techniques: Mutagenesis, Control

Journal: bioRxiv

Article Title: SomaScan Bioinformatics: Normalization, Quality Control, and Assessment of Pre-Analytical Variation

doi: 10.1101/2024.02.09.579724

Figure Lengend Snippet: Venn diagram showing the SOMAmer overlap (based on “SeqId” identifiers) between the 1.3K, 5K, 7K, and 11K SomaScan assays.

Article Snippet: For each human protein SOMAmer in the plasma 7K assay, we calculated the Spearman’s correlation between the fully normalized RFU values from the adat file provided by SomaLogic using external references (a file designated with the “hybNorm.medNormInt.plateScale.calibrate.anmlQC.qcCheck.anmlSMP” suffix) and the full normalization described here using internal references (“hyb.msnCal.ps.cal.msnAll”).

Techniques:

Journal: bioRxiv

Article Title: SomaScan Bioinformatics: Normalization, Quality Control, and Assessment of Pre-Analytical Variation

doi: 10.1101/2024.02.09.579724

Figure Lengend Snippet: Distribution of Spearman’s correlation estimates for the 7,289 human protein SOMAmers in the 7K plasma SomaScan assay, calculated over nearly 1,800 human donor samples from the BLSA . For each SOMAmer, the correlation was calculated between the fully normalized RFU values from SomaLogic’s pipeline using external references and the full normalization described here using internal references.

Article Snippet: For each human protein SOMAmer in the plasma 7K assay, we calculated the Spearman’s correlation between the fully normalized RFU values from the adat file provided by SomaLogic using external references (a file designated with the “hybNorm.medNormInt.plateScale.calibrate.anmlQC.qcCheck.anmlSMP” suffix) and the full normalization described here using internal references (“hyb.msnCal.ps.cal.msnAll”).

Techniques: Clinical Proteomics